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The Indian Health Service (IHS), part of the Department of Health and Human Services (HHS), has reorganized its structure, particularly focusing on its Office of Quality. This reorganization aims to enhance the functions of the IHS in areas such as legislative affairs, quality improvement, patient safety, risk management, and compliance. Key divisions under the Office of Quality now include the Division of Quality Assurance and Patient Safety, Division of Enterprise Risk Management, Division of Innovation and Improvement, and Division of Compliance, each with specific roles to improve health outcomes and operational standards within the IHS. Roselyn Tso, the Director of IHS, has confirmed that all prior delegations of authority remain effective unless changed by the reorganization.

The Administration for Children and Families (ACF) has reorganized its Office of Planning, Research, and Evaluation (OPRE) by establishing a new Office of Research and Evaluation (ORE) and the Office of the Chief Data Officer (OCDO). This reorganization aims to enhance guidance, research, and data management related to programs designed to improve the lives of children and families. The OPRE will now focus on strategic planning, research, and evaluation while maintaining and supporting other divisions related to economic independence, child and family development, and family strengthening. The OCDO will handle data governance and enhance data usage to improve program effectiveness and efficiency.

The Administration for Children and Families (ACF) has reorganized the Office of Child Care (OCC) by adding a new Regional Operations Division. This change involves moving impacted staff from the Office of the Director to the newly established division. The OCC is responsible for overseeing various child care programs and supporting grantees' efforts to provide subsidies for low-income families, improve child care quality, and support the workforce. This reorganization maintains the existing policies and re-delegations of authority within the ACF and ensures continuity in their operations.

The Foreign-Trade Zones Board has approved an application to reorganize Foreign-Trade Zone 123 in Denver, Colorado, under the alternative site framework. This decision allows the World Trade Center Denver to manage a service area that includes several counties and categorize certain existing sites as magnet or usage-driven. The approval includes conditions such as a 2,000-acre activation limit and specific sunset provisions requiring sites to be activated or have foreign-status merchandise admitted within a set number of years. This ensures that the sites will indeed be used for foreign-trade purposes.

The Indian Health Service (IHS), part of the Department of Health and Human Services, has announced a reorganization of its headquarters, specifically focusing on the Office of Information Technology (OIT) and the Office of Management Services (OMS). The reorganization aims to update structures, improve efficiency, and align with current technology and administration requirements. The new structure, approved by the Secretary of Health and Human Services, will streamline operations within these offices to better serve the healthcare needs of Indian communities. This change involves various functions like cybersecurity, records management, emergency preparedness, and asset management, enhancing the IHS's ability to support healthcare services.

The Department of Health and Human Services (HHS) has updated its Statement of Organization for the Office of the General Counsel (OGC). This update clarifies the roles, responsibilities, and structure of the OGC, including the addition of their participation in the Inter-Agency False Claims Act Working Group. Key components such as the Mission, Organization, and Functions of the OGC are detailed, emphasizing the legal services provided to the Secretary and other parts of the department. The revised document also outlines how it nullifies all previous statements of organization.

The National Institutes of Health (NIH) has restructured its All of Us Research Program, moving it from the NIH Office of the Director to the Division of Program Coordination, Planning, and Strategic Initiatives. This reorganization was approved by the Secretary of Health and Human Services in December 2024. Additionally, they established a new program office focused on environmental health impacts on children. The changes aim to improve research efforts and enhance collaboration among different health initiatives.

The Indian Health Service (IHS) has reorganized its structure to improve the management and operations of the Office of the Director’s Intergovernmental Affairs functions. This reorganization aims to enhance the efficiency and effectiveness of its services, particularly those related to Indian Self-Determination and Education Assistance Act (ISDEAA) programs, Tribal and Urban Affairs, and External Affairs. The changes involve various divisions and staff, including those focused on Diversity Management, Tribal Payments, and Public Engagement, to better coordinate with Tribal governments and organizations while also aligning its efforts with federal regulations and policies.

The Administration for Children and Families (ACF) under the Department of Health and Human Services (HHS) has announced a reorganization to create the Unaccompanied Children Office of the Ombuds (UCOO). This new office will be led by a Director, or "Ombuds," and will oversee issues related to the care and custody of unaccompanied children. The UCOO will investigate reports and work with the Office of Refugee Resettlement (ORR) to resolve concerns. Additionally, it will provide recommendations to improve policies and ensure the protection of unaccompanied children.

The Food and Drug Administration (FDA) has reorganized its Center for Drug Evaluation and Research (CDER), specifically within the Office of Medical Policy (OMP), which was approved by the Secretary of Health and Human Services on November 19, 2024. This reorganization aims to improve the FDA's ability to conduct its public health mission by enhancing its capacity to innovate in clinical trials, using tools such as Artificial Intelligence (AI) and Digital Health Technologies (DHTs). The Division of Clinical Trial Quality has been renamed to the Division of Clinical Innovations to support this focus. This restructuring is intended to foster collaboration, attract a diverse workforce, and modernize policy development to guide innovative drug development practices.